Role of antibody screening in high titre group O donors
نویسندگان
چکیده
Red Cells, Fresh Frozen Plasma (FFP) and Platelets (RDP/SDP) prepared from donors with group O may have high titers of anti-A, anti-B and/or anti-A,B antibodies. When such components given to non-group patients, this titre can result in haemolytic transfusion reactions (HTRs). Such are generally termed ‘high-titer donors. Significant amounts ABO antigen being present on the platelet surface anti-ABO iso-agglutinins donor’s plasma, Platelet transfusions need take into account issues. Although relatively rare, but acute intravascular reaction has been caused by passive transfer anti-A antibodies, This study aimed identify prevalence antibodies Thus, performed randomly selected different gender age best available source products for follow up transfusions. : Randomly 100 blood were included study. Samples these tested antibody (both IgM IgG) titres using conventional tube technique at RT 37°C Indirect Antiglobulin phase. Statistical analysis was two sample t-test anova test. Donors mainly male (85%) ranged 0 2048. In study, Anti-B (IgG) titer is significantly higher than other both genders. There a large proportion having hence routine pretransfusion screening prevent development hemolytic issuing only low out Each Blood Transfusion Service should establish policy testing issue platelets non-O recipient avoid chances adverse reaction.
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ژورنال
عنوان ژورنال: Journal of diagnostic pathology and oncology
سال: 2023
ISSN: ['2456-6284', '2581-3706', '2581-3714']
DOI: https://doi.org/10.18231/j.jdpo.2023.016